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(2010) Proc Natl Acad Sci USA
Quizartinib
injection of S3I-201 (NSC-74859) or vehicle every 2 or every 3 days for 2 weeks
CC1(N)CCN(CC1)C1=CN=C(C2=CC=CC(Cl)=C2Cl)C(N)=N1
DASA-58 (ML203) - Pyruvate Kinase M2 (PKM2) Activator. CAS# 1203494-49-8 size:2 mg solid (2010) Proc Natl Acad SciDASA 58 (ML203), CAS No. 1203494 49 8, is a potent and selective Pyruvate kinase M2 (PKM2) activator with EC50 ~38 nM. It can stabilize pyruvate kinase subunit interactions, promote PKM2 tetramer formation and prevent inhibition by phosphotyrosine signaling. It can alter metabolism in cultured cells, and inhibit xenograft tumor growth in vivo. DASA 58 inhibits LPS induced Hif 1 and IL 1, as well as the expression of a range of other Hif 1 dependent
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